[2] She began playing music in her adolescence and moved to Los Angeles at the age of 18, where she founded the punk rock band The Distillers.

[4] Dalle's maternal grandfather was Giacomo Costa, an Italian Australian professional wrestler best known by his ring name, Al Costello, and the creator and original member of the tag team The Fabulous Kangaroos.

[citation needed] Her parents later married other people; through her father's second marriage, she is the older half-sister of actress Morgana Robinson.

[13] She participated in Rock 'n' Roll High School (RnRHS), a Melbourne feminist collective started by Stephanie Bourke.

[18] In 2001, Dalle also made a cameo in New Found Glory's music video "My Friends Over You" with then-husband Tim Armstrong, as well as his bandmates from Transplants, Travis Barker and Rob Aston.

On 11 December 2008, the band released their first EP entitled Ghetto Love, with an accompanying video directed by Liam Lynch.

[20] Dalle has also played on tracks for the band Eagles of Death Metal under various monikers and appeared on the song "Weigh on My Mind" on the Transplants' debut album in 2002.

In 2009, she made an appearance in the same song as her husband, Josh Homme, on "Bargain Healers" from the French artist Nosfell on his self-titled album.

In November 2012, Dalle announced on Twitter that she was working on a solo album, featuring Alain Johannes, Michael Shuman of Queens of the Stone Age, and Shirley Manson of Garbage.

[citation needed] In November 2013, Dalle announced that she had signed to Caroline Records, a division of Universal Music Group, intending to release her debut solo album in early 2014.

[21] The album was produced by Alain Johannes, and features guest appearances from Shirley Manson of Garbage, Nick Valensi of the Strokes, and Warpaint's Emily Kokal.

[32] Dalle requested that restraining orders be filed against him on behalf of their sons in September 2021, alleging physical and emotional abuse,[33][34] but was denied by two judges.