The screenplay by Samson Raphaelson and Ernest Vajda is based on the 1930 play L'homme que j'ai tué by Maurice Rostand and its 1931 English-language adaptation, The Man I Killed, by Reginald Berkeley.

Haunted by the memory of Walter Holderlin, a soldier he killed during World War I, French musician Paul Renard (Phillips Holmes) confesses to a priest (Frank Sheridan), who grants him absolution.

As anti-French sentiment continues to permeate Germany, Dr. Holderlin (Lionel Barrymore) initially refuses to welcome Paul into his home, but changes his mind when his son's fiancée Elsa identifies him as the man who has been leaving flowers on Walter's grave.

The film's original title, The Man I Killed, was changed to The Fifth Commandment to avoid giving "wrong impressions in the minds of the public about the character of the story."

[3] Mordaunt Hall of The New York Times called the film "further evidence of Mr. Lubitsch's genius, for, while it is tearful, its story is unfurled in a poetic fashion, with an unexcelled performance by Lionel Barrymore and fine acting by Phillips Holmes and Nancy Carroll."