Brome-Missisquoi (French pronunciation: [bʁɔm misiskwa]) is a regional county municipality in the Estrie region of Quebec, Canada.

In Parliament it is covered by the Brome—Missisquoi federal electoral district.

In the 1980s, the RCM was formed from municipalities of historic Brome and Missisquoi counties.

On January 1, 2010, the city of Bromont moved from La Haute-Yamaska Regional County Municipality to Brome-Missisquoi.

Highways and numbered routes that run through the municipality, including external routes that start or finish at the county border:[12]