Its current formulation contains the pain reliever aspirin and two reactive chemicals – sodium bicarbonate and citric acid – which creates effervescence when mixed with water.
[2] Acetanilide was replaced with its metabolite acetaminophen, and its current formulation uses aspirin, sodium bicarbonate, and citric acid, the latter two of which provide the carbonation.
Bromo-Seltzer's main offices and factory were located in downtown Baltimore, Maryland, at the corner of West Lombard and South Eutaw streets.
Drugstore Bromo-Seltzer dispensers are mentioned in Georges Simenon's 1949 detective novel Maigret chez le coroner that takes place in Arizona.
It is mentioned in several songs, including "Bewitched, Bothered and Bewildered" by Rodgers and Hart, "Adelaide's Lament" in the musical Guys and Dolls, and "Pachuco Cadaver" by Captain Beefheart and his Magic Band.