She has appeared in musical theatre, including the US tours of Beauty and the Beast and Wicked, and the Broadway productions of Taboo and The Pirate Queen.

She is known for her roles as Jane Bingum on the Lifetime series Drop Dead Diva (2009–2014) and as Dana Sue Sullivan in the Netflix romantic drama Sweet Magnolias (2020–present).

Elliott went on to Western Michigan University, and graduated with a Bachelor of Fine Arts in Musical Theatre Performance in 1998.

[12] Producer Craig Zadan said of Elliott's casting, "We had to find somebody who's a beautiful leading lady, who can do the comedy and drama, and with Brooke, she nailed it".

[20] In 2016, Elliott starred opposite Katey Sagal in the CBS comedy pilot Upper Middle Bogan inspired by the Australian series.

In 2018, she went to star in the ABC comedy pilot created by Bobby Bowman about a dysfunctional family struggling with mental illness.

[25] During her time as the leading character in Drop Dead Diva, Elliott has discussed the perception of plus-size actresses on television,[12] and describes her body type as normal sized, stating "The majority of women in America look like me.