Brooke Megan Greenberg (January 8, 1993 – October 24, 2013)[1][2] was an American woman who became famous for being the first documented case of neotenic complex syndrome.

Brooke was born on January 8, 1993,[1][3] to parents Howard and Melanie Greenberg[4] at Sinai Hospital in Baltimore, Maryland.

She was born with anterior hip dislocation, a condition that caused her legs to be swiveled upward toward her shoulders; it was corrected surgically.

Brooke's pediatrician, Dr. Lawrence Pakula, stated that the source of her sudden illness remains a mystery.

[9] Over several years, the Greenbergs visited many specialists, looking for an explanation for their daughter's strange condition, yet there was no diagnosis of any known genetic syndrome or chromosomal abnormality.

[10] In 2001, when Dateline documented Brooke at eight years of age, she was still the size of a six-month-old infant, weighing just 13 lb (5.9 kg) at 30 inches (76 cm) tall.

The Greenbergs made many visits to nearby Johns Hopkins Children's Center and even took Brooke to New York's Mount Sinai Hospital, searching for information about their daughter's condition.

[6] When geneticists sequenced Greenberg's DNA, they found that the genes associated with the premature aging diseases were normal, unlike the mutated versions in patients with Werner syndrome and progeria.

[11] In 2006, Richard Walker, an endocrine physiologist at the University of South Florida College of Medicine, said that Brooke's body was not developing as a coordinated unit but as independent parts that were out of synchronization.

Her funeral service took place on October 27, 2013, and that same morning, she was buried at Baltimore Hebrew Cemetery - Berrymans Lane, in Reisterstown, Maryland.

[2] The cause of her death was bronchomalacia, a medical condition usually occurring in children, which results in difficulty breathing due to weak cartilage in the walls of the bronchial tubes.