The Primary Flying School continued operation until 1931 when it moved to Randolph Field in San Antonio.
SAM aided the National Aeronautics and Space Administration (NASA) with Project Mercury and served as a back-up site for lunar samples brought back to Earth on the Apollo missions between 1969 and 1972.
The air evacuation program at Brooks AFB proved vital to the care of wounded personnel in the Vietnam War.
President John F. Kennedy dedicated the School of Aerospace Medicine on November 21, 1963, the day before he was assassinated in Dallas, Texas.
[5] After the Vietnam War, the base's mission narrowed to one centered on specific research related to U.S. Air Force fliers and personnel.
The Brooks Development Authority has demonstrated economic development success with projects including a 62-acre (250,000 m2) retail development, approximately 256,000 square feet (23,800 m2) of research and distribution facilities for DPT Laboratories, the South Texas Center for Emerging Infectious Diseases (an infectious disease research institute coordinated with the University of Texas at San Antonio), an international pharmaceutical company, and a $25.5 million City/County emergency operations center which opened in the Fall 2007.
The United States Postal Service Post Office at 8060 Aeromedical Road closed in late May 2011.