In addition to the twenty-three regular episodes in season one, a special, "The Beautiful World of Ugly Betty", was aired on April 12, 2007.

Another special, which was a half-hour update recapping the first ten episodes, aired during the month of January 2007 on local ABC affiliates and various cable networks.

Rebecca Romijn was added to the show’s main cast in episode 13, after her character was initially played by (a heavily disguised) Elizabeth Payne.

The 23 episodes, along with bonus footage and unaired extras, are featured in "Ugly Betty: The Complete First Season — The Bettyfied Edition", which is distributed internationally by Buena Vista Home Entertainment.

According to TV Shows on DVD, BVHE released the six-disc set on August 21, 2007 and is available in regions 1 (United States and Canada), 2 (European territories) and 4 (Asia and Australia).