They were born in Iowa and Indiana, grew up in Alberta and Tennessee, and retained Southern accents during their performing careers.
The sisters began a singing career as a trio in Canada, first appearing as child performers in Mother Lang's Children's Show.
The Brox Sisters were among the earliest artists to appear on Warner Bros.' Vitaphone sound shorts in the late 1920s.
In 1929, they appeared in the film The Hollywood Revue of 1929, performing the songs "Singin' in the Rain" with Cliff Edwards and "Strike Up the Band" in the finale of the first act.
They performed the song "A Bench in the Park", with Joe Venuti and Eddie Lang, and with The Rhythm Boys (Bing Crosby, Harry Barris and Al Rinker).