He was appointed club captain ahead of the 2012–13 season and remained in the role until 2014 when he signed for Championship side Cardiff City for €5 million.

Manga made his international debut for Gabon in 2006 and has accumulated over 100 caps to date, representing the side at four Africa Cup of Nations tournaments.

Ecuele Manga began his career in his homeland with FC 105 Libreville, before being recommended to French Ligue 1 side Girondins de Bordeaux by Alain Giresse who was manager of the Gabon national team.

[5] After being involved in the club's preseason fixtures under manager Laurent Blanc,[5] Ecuele Manga made his competitive debut for Bordeaux, making his first start, in the Matchday Six, in a 3–2 win over Panionios.

[18][19] Ecuele Manga made his Lorient debut in the opening game of the season, making his first start, in a 2–2 draw against Auxerre.

[20] Ecuele Manga was soon sidelined after injuring his hamstring in training, an injury that caused him to miss two matches in late-November.

[22] After making his return in a 3–3 draw against Arles-Avignon on 12 March 2011, Ecuele Manga scored his first Lorient goal, in a 3–1 loss against Montpellier on 11 May 2011.

"[44] With a one-year contract left at Lorient, there is slim chance for Ecuele Manga leave at the end of the transfer window.

[45] On 1 September 2014, Bruno Ecuele Manga signed for Welsh club Cardiff City for €5 million, keeping him until 2017.

[46] Ecuele Manga then made his Cardiff City debut, making his first start, in a 1–0 loss against Middlesbrough on 16 September 2014.

[47] Ecuele Manga scored his first Cardiff City goal, in a 3–1 win over Leeds United two months later on 1 November 2014.

[48] However, Ecuele Manga was on the sideline after injuring his knee during a match against Bolton Wanderers and his international commitment[49][50] and made his return for his thirteenth start of the season, in a 3–2 loss against Brentford on 20 December 2014.

[58] Ecuele Manga made his return to the first team coming on as a substitute for the injured, Sean Morrison against Birmingham City.

[59] Despite another injury ridden season, Ecuele Manga was offered a new contract by manager, Neil Warnock, which was signed on 27 June 2017.

Manga scored Cardiff's first goal of 2018–19 season in a 3–1 loss to Norwich City in the Football League Cup.