A backup option in his first season, Bruno Henrique became a regular starter for the club in 2010, and scored his first senior goal on 18 July of that year, netting Iraty's winner in a 2–1 Série D home success over Pelotas.

[2] On 30 January 2011, Bruno Henrique scored a brace in Iraty's 3–0 away win over Cascavel CR, and finished the year's Paranaense with seven goals.

In 2011, Bruno Henrique signed with Londrina on loan, being a part of the club's Campeonato Paranaense Série Prata winning campaign as a starter.

[12] He was only presented by his new club on 11 February,[13] and made his debut for Timão five days later, starting in a 1–1 home draw against rivals Palmeiras in the Campeonato Paulista.

[17] On 29 August 2016, Bruno Henrique moved abroad and signed a four-year contract with Palermo in the Italian Serie A,[18][19] for a rumoured fee of € 3.3 million.