[1] In 2013–14, he made his debut in Serie A2 with PMS Torino under head coach Stefano Pillastrini.
On 24 September 2023, after having ousted Olimpia Milano in the semifinals, Virtus won its fourth Supercup, and the third in a row, defeating 97–60 Germani Brescia.
[4] On 7 December 2023, Mascolo made his debut in EuroLeague against FC Barcelona, scoring two points.
[6] On 10 November 2021 he was called up to coach Meo Sacchetti's long list in Italy's national basketball team in view of the 2023 FIBA Basketball World Cup qualifications,[7] becoming the first Neapolitan called up to the national team after 37 years.
Mascolo played 1 career game for Italy's national basketball team in the World Cup qualifications.