Bruno Henrique Santos Sant'Anna (born 12 July 1993) is a Brazilian tennis player.

Sant'Anna has a career high ATP singles ranking of 337, achieved on 7 October 2013.

Sant'Anna made his ATP main draw debut at the 2012 Brasil Open, where he and Rogério Dutra da Silva received a wildcard into the doubles event.

The pair lost in the first round to the second seeds, Daniele Bracciali and Potito Starace, 4–6, 4–6.

This biographical article relating to Brazilian tennis is a stub.