Brusnik (Serbian Cyrillic: Брусник) is a village situated in the Zaječar municipality of the Republic of Serbia (formerly briefly in Negotin District, as it is 37 km from Zaječar and just 21 km from Negotin, which is somewhat similar to the locations of the town of Negotino and the village Brusnik in Macedonia).

Like many other villages in Eastern Serbia, specifically the Timok Valley region, Brusnik has "pivnice"/"pimnice", a separate but attached set of temporary residences, aligned in streets and with shops, but not a school, post office or medical facilities (which remain only in the village itself), located 5 km away from the village proper and used for a month or so during the grape harvesting and wine making season.

Due to their exceptional quality, Brusnik wines were exported to the paramount centre of winemaking, France, as early as the mid-19th century, but today with a sharp decline in population and after the devastating effects of mismanagement during Josip Broz Tito's socialism, Slobodan Milosevic's nationalism, and NATO's illegal destruction of Serbia's infrastructure in 1999 during the Kosovo war, Brusnik's wineries—and economy overall—is devastated (not unlike that in a greater part of Serbia's countryside).

Identified on Austrian maps in the early 18th century as a part of the Banat of Temeswar and listed in the Ottoman Turkish censuses already in the late 16th and throughout the 17th century, and then again immediately after Ottoman reconquest of Eastern Serbia from Austrian Empire in 1741,[1] Brusnik has been the municipal centre for the adjacent villages Tabakovac (mostly Vlach/Wallachian population) and Klenovac (mostly Serbian population, who moved to the region in the 16th century, originally from the Kosovo and Metohija area and Montenegro) since 1833, when it became a part of the Principality of Serbia.

Then after the Tito–Stalin split things changed, and for a few years in the 1950s Brusnik was officially a town again and the seat of the Krajina District composed of over 15 villages,[2] but again, this did not last, as Negotin and especially Zaječar as administrative, cultural, and industrial centres were promulgated by the polity and Brusnik was once again demoted to the status of a village.