Brussels is a village in southern Calhoun County, Illinois, United States.

Brussels is the headquarters location of the Two Rivers National Wildlife Refuge, which is noted for its population of bald eagles.

The school district serves the surrounding communities of Meppen, Golden Eagle, and parts of Batchtown.

Brussels was first settled in 1822, when John Mettz came to the area; later in the same year, Joshua Twitchell established the community's first business, a blacksmith shop.

In 1843, Brussels' population grew significantly due to an influx of German immigrants.

The Wittmond Trading Post, one of the first brick stores in the region, opened in Brussels in 1847, marking the beginning of the village's commercial development.

[4] According to the 2021 census gazetteer files, Brussels has a total area of 0.56 square miles (1.45 km2), all land.