[1] Brussels was settled in 1854, when William Ainley purchased 200 acres of land alongside the Maitland River.

Huron County Road 12, called Turnberry Street (in-town) and Brussels Line (out-of-town) runs north–south through the town while Huron County Road 16 runs west–east through the town with a distinct name depending on the direction.

The Maitland River runs through the town in a south to north direction which has resulted in the construction of a dam in the community.

The river and low-land areas of the dam typically floods every spring from increased rainfall and snow melt.

It is also 39 km (24 mi) east of the closest coastal community, Goderich on the shorelines of Lake Huron.

As Brussels is a rural community, farmland surrounds the town on all sides with scattered bushes amongst the fields.