After a range of entrepreneurial activity, including founder and manager of the Club 69 nightclubs in Madang and Lae (where Lands Minister John Rosso and Health Minister Jelta Wong were regulars), Organising Committee Member of the Miss PNG franchise of the Miss Pacific Islands beauty pageant (with Dadi Toka Jr) and roles with major accounting firms and in his uncle's civil engineering and construction company, Kramer Ausenco, he contested the seat of Madang Open in the 2007 Papua New Guinea election, at the age of 31.

In June 2018 Kramer launched an offensive against Papua New Guinea's daily newspapers, The National and Post-Courier, calling for a boycott to protest corruption and their support for the O'Neill Government.

[15] The incident, which became known as Maseratigate,[16] received international attention and ongoing coverage, particularly after it was revealed a number of vehicles procured for APEC had subsequently gone missing.

[18] In February 2019, Kramer released an analysis of costs related to the destruction of PNG Parliament Haus property by security personnel shortly after APEC activities ended.

[27] From the time he was elected, Kramer mounted a sustained campaign to undermine the leadership of then Prime Minister Peter O'Neill citing corruption and insider dealing.

[28] This and increasing dissatisfaction with O'Neill's dealings from within his own party saw opponents coalesce around allegations of corruption in a leaked Ombudsman's report investigating the purchase of Oil Search shares by the State in 2014.

[29] The leak prompted a split in O'Neill's People's National Congress Party, led by former Finance Minister James Marape.

Kramer worked closely with the opposition (predominantly National Alliance members), Marape and Pangu Pati to trigger O'Neill's resignation on 26 May 2019.

"[40] After a period in Australia, and after calling for Kramer's removal, O'Neill returned to Papua New Guinea but did not appear for the final sitting of Parliament.

[42] After an extended period in Australia, O'Neill returned to Papua New Guinea on 24 May 2020 and was immediately arrested by police in relation to the purchase of two generators from Israeli interests.

He subsequently returned to PNG Parliament during its June sitting and challenged the Marape-Steven Government over a range of issues from debt escalation to the management of the COVID-19 crisis.

This would defer sitting until a Vote of No Confidence was allowed and the Opposition could attempt to remove Marape and replace him with a new Prime Minister.

[50] Pomat convened Parliament on Monday 14 December, which was disrupted by arguments over the status of Opposition member Bari Palma, who was an undischarged bankrupt when elected and may have been ineligible to stand.

[53] Throughout these events, Kramer remained a Government stalwart and used his Facebook page to interrogate court proceedings and sew dissent through Opposition ranks; his "hug" with Madang Governor Peter Yama after Yama crossed the floor was noted as one of the more surprising events of the day, given each had outstanding court actions against the other.

[57] He removed long-term acting Police Commissioner Gari Baki in July 2019, saying he was past compulsory retirement age and needed to be stood down.

[60] Concerned about ongoing mismanagement of police finances, in June 2020 Kramer called the Fraud Squad to task about high rental costs.

After investigation, Kramer determined that a company owned by a foreign national was charging high and escalating rents on a building leased by the Fraud Squad.

[61] In August 2020 the Royal PNG Constabulary and Australian Federal Police jointly undertook one of the largest drug busts in both countries' histories, with over 500 kg of cocaine seized from a Cessna light aircraft that crashed shortly after takeoff on a secluded runway in Papa Lealea, Central Province.

[63] In September 2020 Kramer launched a broadside on Facebook against his own police department,[64] which was subsequently reported in the international media.

They were implicated in organised crime, drug syndicates, smuggling firearms, stealing fuel, insurance scams, and even misusing police allowances.

[70] The program, a collaboration with the Australian Government, upgrades key police stations installing modern equipment such as biometric staff movement logging, dashcams and GPS monitoring systems.

[74] Kramer pursued a number of high-profile cases as Minister for Justice, his department working with the RPNGC's newly formed Special Police Forensic Criminal Investigation Team.

Australian national and former high-profile acting Managing Director of PNG Power, Carolyn Blacklock, was arrested on charges of conspiring to forge an employment contract and defrauding the State of over PGK1.7 million.

"[76] Kramer brought a record number of submissions to the National Executive Council and Parliament during his term as Minister, with Attorney-General and Secretary for Justice Dr Eric Kwa saying that "We have checked the records and confirmed that this is the first time in the history of the Department [that] we have had more submissions and decisions taken up to the Cabinet since Minister Kramer took office."

[77] Kramer was appointed Minister for Immigration and Citizenship on 13 April 2022, in a minor cabinet reshuffle shortly before the issue of writs for the PNG National Election 2022.

[89] Kramer has repeatedly refuted these claims, including by posting on Facebook a letter from Australia's Department of Home Affairs confirming that he was not, nor had he ever been, an Australian citizen.

He further found that funds allocated appeared to have been misapplied, under-applied or ineffectively applied, and that there had been problems with the capacity/or integrity of the contractors engaged in the past.

Cannings further stated that "I accept the evidence of the Member of Madang Open Bryan Kramer MP, that he has taken initiative and been proactive and assertive in securing funds necessary to at least address the problem of Modilon Road.