He played college football for the Penn State Nittany Lions and was selected by the Atlanta Falcons in the second round of the 2003 NFL draft.

He averaged nearly 20 points per game in basketball as a senior and was a Pennsylvania state prep medalist in the 100- and 200-meter dashes.

On April 6, 2006, Scott was traded to the New Orleans Saints for OT Wayne Gandy and a 2007 conditional late round draft choice.

Bryan is also the Entrepreneur who appeared on the famous CNBC TV show, Sharktank, to pitch his Noene shoe insoles.

The duo lost to Doug Flutie and Barenaked Ladies in the finals after competing against a host of other NFL players and recording artists in a round-robin competition.

Scott sang a song he wrote at the funeral service for Kevin Dare, the Penn State pole vaulter who died while competing at the Big Ten Indoor Track and Field Championships in February 2002.

To launch the foundation, Bryan recorded a music single Dedicated, written and produced by his brother Brandon Scott.

His cousin, Ryan Stewart, is a former defensive back with the Detroit Lions (1996–99) and current radio personality in Atlanta, Georgia.

He appeared on the April 24, 2015, episode of the television show Shark Tank, and made a deal with Mark Cuban and Daymond John for them to become involved in the company.