As of July 1, 2022, the Bulldogs compete in most National Collegiate Athletic Association (NCAA) Division I sports as members of the America East Conference (AmEast).

Bryant competed in the NE-10 from the conference's founding in 1980 until 2008 when the university began the transition to Division I.

During their NAIA playing years, they were known as the Indians, and were located in Providence, Rhode Island, near Brown University.

With the conference affiliation Bryant was able to keep its closest present-day rival Bentley College Falcons close both academically and athletically.

[5] Entering the 2000s (decade) the university has won 40 conference championships; and the President's Cup 4 times in 2004, 2005, and 2007 and in their last season as a Division II member in 2008.

In their last year of competition in Division II and in the Northeast-10, Bryant won the President's Cup by over 30 points, and sent 19 out of the 22 teams into the NCAA playoffs.

[9] On March 29, 2022, Bryant was announced as a new member of the America East Conference (AmEast), effective that July 1.

[2] It is the only private school in the AmEast following the 2022 departure of Hartford, which started a transition from D-I to Division III in 2021 and left to spend one year as a D-I independent before joining the D-III Commonwealth Coast Conference, now known as the Conference of New England, in 2023.

The Southland Conference brought the Bulldogs in as members in men's & women's golf and tennis.

A member of the America East Conference, Bryant University sponsors teams in 25 NCAA-sanctioned sports, 11 for men and 14 for women:[17] Bulldog Stadium was completed in 1999 and has a seating capacity of 5,500 with a 4,200-seat permanent structure and press box on the home side of the field and 1,300 additional seats on the visitor's side.

[18] Conaty Park, the home of Bryant's baseball program, is located in the northwest section of the campus near the other athletic facilities.

[20] The Elizabeth & Malcolm Natatorium is an olympic-size pool originally constructed with the additions to the current Wellness and Athletic Center.

[21] The pool had only recreational use until the winter of 2005 when Bryant added men's and women's swim teams as a varsity sport.

The natatorium features six lanes equipped with a scoreboard, seating area, and sound system.

[24] Tupper served as Bryant University's mascot and attended campus events, as well as performed community service as a therapy dog.

[24] He was the first live bulldog mascot in the university's history and received an honorary degree at 2010 commencement for "character and obedience.