They made successful recordings with singer Margie Day, and had a no.1 hit on the Billboard R&B chart in 1951 with "Weepin' and Cryin'", featuring Tommy Brown.
In the late 1940s they played local clubs in Washington, D.C., as well as Virginia and North Carolina, and added a singer, Margie Day.
[5][3] The follow-up record, "Little Red Rooster", not directly related to the Willie Dixon song but drawing on the same folk traditions, reached no.5 on the R&B chart in early 1951.
Wilson, Reeves and Shields were replaced by Noble "Thin Man" Watts (tenor sax), Wilbur Little (bass), and Belton Evans (drums).
[6] The Griffin Brothers toured widely in 1951 and 1952 with Amos Milburn, Paul Williams and others, and continued to record both with Margie Day, and with singer Tommy Brown.