The Buell Children's Museum is a part of The Sangre de Cristo Arts & Conference Center which opened in 1972, with funding provided by the Economic Development Administration and Pueblo County.

In 1982, an expansion, funded by Puebloan Helen T. White, added three galleries, a gift shop and a small precursor children's museum.

In 2000, a further expansion added the 12,000 square-foot, two-level Buell Children's Museum and the Jackson Sculpture Garden.

The Buell Children's Museum offers 7,500 square feet of interactive gallery space, a theater, a café and a gift shop.

In 2004, the museum was named the winner of the Award of Excellence in Arts & Humanities by the El Pomar Foundation.