The station serves six Amtrak trains daily: two daily Empire Service round trips between Niagara Falls and New York City and one Maple Leaf round trip between Toronto and New York City.

There is also daily Amtrak Thruway bus service (operated by Coach USA) at the station, operating between the Buffalo Metropolitan Transportation Center and Jamestown station in Jamestown, New York, via Dunkirk and Fredonia, and serving the communities along the southeast shore of Lake Erie.

The biggest issue with the Exchange Street site at the time aside from the station's small size for being the main station in Buffalo was that it was plagued with downtown congestion as the crossings in and out of the area were at grade and therefore had to contend with busy city streets.

[7] The station's importance declined after Buffalo Central Terminal which was built to solve the issues at the Exchange Street site opened in 1929.

[9] The station originally served 21 New York Central and Toronto, Hamilton & Buffalo Railway trains daily.

One old platform was reused immediately; a temporary structure was used for Niagara Rainbow and Empire State Express passengers while the station building was renovated.

[14] On April 17, 2017, a panel including Buffalo mayor Byron Brown approved the downtown location.

[15] The New York State Department of Transportation awarded a $27.7 million design-build contract in December 2018.

The first train to stop at the station was the eastbound Maple Leaf, arriving at 12:55 p.m. Assemblywomen Crystal Peoples-Stokes, Lieutenant Governor Kathy Hochul, Mayor Byron Brown, and State Senator Tim Kennedy attended the ribbon cutting.

There is a waiting room on the east side of the building, designated drop-off and pick-up zones, and an area for 14 canopied parking spaces for Greyhound, Trailways and NFTA buses if they are later added.