The hotel is home to the currently closed Desperado roller coaster, a hypercoaster with a 225-foot drop, and a top speed of 80 mph, a log flume ride, as well as a pool in the shape of a buffalo.

[3] The ribbon cutting for the change of ownership for Primm Valley Resorts from MGM Mirage to Herbst Gaming was held at Buffalo Bill's on April 10, 2007.

[4] Herbst undertook a marketing strategy of appealing especially to California Latinos, including the addition of Spanish-speaking dealers, charter bus trips from the Inland Empire, concerts by norteño musician Ramón Ayala, and a Mexican restaurant branded with Ayala's name.

[5] The interiors and exteriors of the casino were used in the movie Top of the World (1997) starring Peter Weller, Dennis Hopper and Tia Carrere.

In March 2019 Cuca's Mexican Food, originally from Redlands, California, opened their first hotel location in Nevada within Buffalo Bill's.

Starting in December of 2024, Buffalo Bill’s changed the casino hours, closing during the week (Monday-Thursday,) and is currently operating only on weekends (Friday-Sunday.)

In the 1990s, the vehicle was exhibited for several years at Primm Valley Resort[8] and Terrible's Gold Ranch Casino in Verdi[9] before being returned to Whiskey Pete's in July 2011.