The BNMC was founded in 2001 by a consortium (including the University at Buffalo School of Medicine and Roswell Park Comprehensive Cancer Center).

[1] The Medical Campus encompasses 6.5 million square feet of existing clinical, research, and support space today.

[1] In January 2016, The Buffalo News reported the Buffalo-Niagara region's unemployment in December 2015 was only 4.9 percent, the lowest level in nine years according to the New York State Department of Labor.

The low unemployment was attributed to large building projects such as SolarCity and the Buffalo Niagara Medical Campus which fueled a hiring boom for construction workers with job growth running at an average pace of 1.6 percent which is more than double the rate of hiring during 2014 and nearly three times stronger than the employment gains during both 2012 and 2013.

[4] It is estimated that by 2017, combined with the initiatives of Roswell Park Comprehensive Cancer Center and UB 2020, employment on the Buffalo Niagara Medical Campus could exceed 17,000, close to that of the Bethlehem Steel plant in Lackawanna, NY before its closure.