The Joseph C. Ferguson School is an historic American school building that is located in the Cecil B. Moore neighborhood of Philadelphia, Pennsylvania.

[1] Designed by Irwin T. Catharine, this historic structure was built between 1921 and 1922.

It is a three-story, nine-bay, U-shaped, brick building that sits on a raised basement.

[2] The school is named after Joseph C. Ferguson a judge that was a part of Philadelphia orphan court.

Building 21 relocated after three academic years, and The U School remains.