Starting at the Square of Nikola Pašić, it goes for the most part in a south-east direction, curving only near the end, in the neighborhood of Mali Mokri Lug, after which the Bulevar extends into the road of Smederevski put, which connects Belgrade with the city of Smederevo.

[4] Singidunum's castrum occupied part of today's Belgrade Fortress, but the civilian zone spread from the Kralja Petra Street, over the both Sava and Danube slopes, till Kosančićev Venac, extending in a series of necropolises from Republic Square, along the Bulevar kralja Aleksandra all the way to the Mali Mokri Lug.

In 2007, on the location of the former kafana Tri lista duvana at the corner of Bulevar Kralja Aleksandra and Kneza Miloša Street, several necropolises were found.

[8] When the Ottomans regained Belgrade in October 1813, after the collapse of the First Serbian Uprising, their advance guards burned wooden hovels in Savamala neighborhood, engulfing the city in smoke.

When the main Ottoman army landed, a large number of people got stranded on the bank in Savamala, trying to flee across the Sava into Austria.

The mosque itself was demolished after the 1862 Ottoman bombing of Belgrade, making the buildings behind it visible, but the name Bataldžamija for the neighborhood survived into the early 20th century.

The hill in the direction of modern Seismology Institute was allocated for the graves of soldiers, drowning victims, suicides and non-Christians in general, except for the Jews, who had their own cemetery.

[14] As population settled along the road, gradually it became a street, originally known as Sokače kod zlatnog topa ("Alley at the golden cannon").

The house of the quilt maker Laza Mitić, in the center of the orchard on the slope to the stream of Bulbulderski Potok, and Antulina Vila, surrounded by vineyards, were the only two edifices in this area until 1910.

Owned by Tričko Puškar, it was opened several years after the first automobile arrived in Belgrade on 3 April 1903 and was located a bit down from the kafana "Tri lista duvana".

Sculptural group "Black horses at play", work of Toma Rosandić, were placed at the main entrance of the assembly in 1938, facing the boulevard.

[22] The design was selected in April 2022, but apart from two buildings towering over the side, Karnegijeva Street, the appearance of the complex facing the boulevard will remain the same.

The largest such pool was built along the Bulevar, between the buildings of the Main Post Office and National Assembly, where part of the Takovska Street is today.

[27] The building was envisioned as the massive structure, which was to have a pedestrian pathway to the Saint Mark's Church, and to "dominate this part of the city" as the "etalon of the new architecture's superiority".

[26] After the idea of the congress center was abandoned, architect Dragiša Brašovan revised the plans and adapted the structure as the highrise hotel.

Miladin Prljević was given the task of reducing the project, so he downsized it from five huge buildings to two, one to exhibit paintings and sculptures, and the other for medieval collection.

[31] During the period of Yugoslav Wars and sanctions against Yugoslavia in the 1990s, the sellers of the used and cheap goods were selling it on the sidewalks and on the hoods of the cars, turning part of the street into an open flea market again.

[4] In the spring of 2014, former city manager Aleksandar Bijelić, and several of his collaborators, were arrested and indicted, in connection with the negotiations for the 2010 reconstruction which cost 1.7 billion dinars (€16.8 million).

[4][33] By March 2020, the Court of Appeals quashed the prosecutor's indictment two times, also overturning the decision on Bijelić's 11-month long custody.

[34] On 30 August 2021, city assembly voted to erect a monument to Mihajlo Pupin in the boulevard, in front of the Technical Faculties building, at number 73.

[4] A new ultra-modern commercial building is being built on the corner of Kneza Miloša street, formerly kafana "Tri lista duvana" (Three tobacco leaves).

It was badly damaged in Luftwaffe's bombing of Belgrade on 6 April 1941, but later reconstructed and built-on in the 1950s and included into the "protected complex of Old Beograd".

It runs through the neighborhoods of Đeram, Lipov Lad, Lion, Zvezdara, Cvetkova Pijaca, Zeleno Brdo and Mali Mokri Lug.

This part is mostly residential and commercial, with some important facilities located in the Bulevar: Municipal assembly of Zvezdara, open green markets of Đeram, Cvetkova pijaca and Mali Mokri Lug, "Kluz" clothing factory, roundabout of a dozen buses and tramway lines and industrial zone Ustanička (Electrical industry "Nikola Tesla", "Utenzilija", foundry "Livnica", presses of "Glas Javnosti", etc.).

[4][44][45] In the 1990s, with the deterioration of the economic system in Serbia and imposed sanctions, the sidewalks of the Bulevar became the gathering place for the street dealers of all sorts of goods that were unavailable in official stores.

In order to move the illegal sellers from the streets, the city adapted depot into the closed, fair-like shopping center "Depo", with 160 market stalls, in 1996.

[4][44][45][46][47][48] In August 2016 city changed the general urban plan and envisioned the commercial facilities, including a hotel, which was a sign that the Depo will not be reconstructed or preserved.

City refuted those stories claiming that Depo will be rebuilt, in one way or another, as personally confirmed by the mayor of Belgrade Siniša Mali a month after the fire.

[50] The "BKA Development" is a joint venture of two Israeli companies, "Yossi Avrahami" and "Almogim Holdings", which already purchased the lot of the former US embassy in Belgrade, in the Kneza Miloša street, and was founded with the initial capital of only 100 dinars (€0.83).

In the summer of 2018 city announced a drafting of the plan for the much wider area of 1.2 ha (3.0 acres), which occupies the block between the streets of Sinđelićeva, Niška, Sredačka and Bulevar kralja Aleksandra.