[1] Sambamurthy was born on 4 March 1886 in a Telugu Vaidiki Velanadu Brahmin family in Dulla, East Godavari district, Madras Presidency.

Sambamurthy completed his early education in his village and earned a degree in Physics from Maharajah's College, Vizianagaram.

[1] In 1919, at the age of 33, he left his legal practice in response to Mahatma Gandhi's call and joined the Indian independence movement.

In the 1937 Madras Presidency legislative assembly election, Sambamurthy successfully ran for office as a member of the Indian National Congress.

[3] In accordance with Gandhian principles, Sambamurthy adopted a simple lifestyle, wearing a loin cloth and forgoing a shirt.

His funeral was attended by prominent figures, including minister Anagani Bhagavanta Rao, A. Krishnaswami, and district collector Victor.