The Bills defense continued its strong play from last season, finishing first in the league with 54 quarterback sacks.

Three bidders stepped forward with bids: stalking horse bidder Donald Trump, the family of Buffalo Sabres owner and natural gas baron Terrence Pegula and a consortium led by musician Jon Bon Jovi and the principals of Maple Leaf Sports & Entertainment, the last of whom raised serious concerns that the team would relocate to Toronto at the first opportunity.

Bills President and CEO Russ Brandon will evaluate the series in the future, possibly to permanently cancel games in Toronto.

On December 3, 2014, after six years and a 1–5 record (their only win coming in a 23–0 shutout victory against the Washington Redskins), the Bills Toronto Series was permanently cancelled.

The Bills won their first two games, a 23–20 overtime road win at Chicago (their first-ever victory at Soldier Field) and an emotionally raucous 29–10 home win against division rival Miami, a game played just days after the announcement that the Pegulas would purchase the team and keep it in Buffalo.

With running back Bryce Brown, who the Bills traded their conditional fourth-rounder that can become a third-round selection (that they had acquired in the trade that sent Stevie Johnson to San Francisco) to Philadelphia, inactive for the game and no time to find anyone to help carry the ball, running back Anthony Dixon, who the Bills signed as a free agent from San Francisco was left to carry the ball himself, with fullback Frank Summers assisting.

With a win against the Green Bay Packers on December 14, the Bills broke a league-leading streak of nine consecutive losing seasons dating back to 2005; however, the next week's 26–24 loss to the Oakland Raiders eliminated them from playoff contention for the 15th consecutive year, continuing a league-leading drought.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve On February 27, 2014, the NFL announced that, to celebrate the induction of wide receiver Andre Reed, the Bills would play the New York Giants in the Pro Football Hall of Fame Game in Canton, Ohio, which took place on August 3, 2014, and aired on NBC.

After a touchdown by Denver Broncos' running back C. J. Anderson during the December 7 game, two officials acknowledged the call through the use of a fist bump.