succeeded by A 73 and A 70 Bundesstraße 22 (abbreviated to B 22) is a German federal highway that runs from Würzburg (branching off the B 8 near Rottendorf) in Lower Franconia, through the Upper Franconian cities of Bamberg and Bayreuth and the Upper Palatine town of Weiden, to Cham.

The highway acts as a bypass for the Upper Franconian villages of Seybothenreuth and Speichersdorf as well as the Upper Palatine towns of Kemnath, Erbendorf, Oberviechtach and Rötz, running past Cham (Oberpfalz), where it joins the B 20 and B 85 highways.

For military-strategic reasons, it was built parallel to the then German-Czechoslovakian border and was the first north-south route through the Upper Palatine Forest that was suitable for motor vehicles.

The roadbed of the old B 22 from Bamberg to Scheßlitz was downgraded and redesignated as state highway (Staatsstraße) 2190.

The bypass around Eckersdorf is included in the Federal Transport Infrastructure Plan 2030 as a priority need.