Designed by architect W. H. Weeks, the school took in students from Burlingame, Hillsborough, Millbrae, and San Bruno.

In the summer of 1980, the SMUHSD board decided it must close one of the district's seven schools, due to declining enrollment.

Burlingame currently holds "The Paw" as part of a twelve-game win streak, the longest in the rivalry's history.

In September 2017, the Iron Panthers received recognition by competing in the finals of an off-season Robotics competition, Chezy Champs.

[12] In the past three years, the Iron Panthers traveled to Houston to compete in the FIRST Championship and were alliance captains in the 2018 game FIRST Power Up.

[11][12][13] In the 2019 game Destination: Deep Space, they were the winners of the Newton Division and the World Champions; this was the first competition that they won.