Butchertown is a neighborhood just east of downtown Louisville, Kentucky, United States, bounded by I-65, Main Street, I-71, Beargrass Creek and Mellwood Avenue.

For the first 100 years of its existence, Butchertown was a thriving residential and industrial area, though other Louisville neighborhoods regarded it as a haven for drunkards and brawlers.

In the 2000s, there were plans as part of the Ohio River Bridges Project to move the Kennedy Interchange further south when it was to be reconfigured by 2018, meaning that more buildings in Butchertown would be razed.

The necessity of flyover ramps for the new bridge led to the demolishing of about one-third of Butchertown's David Armstrong Extreme Park, along with a rebuild of facilities on an adjacent property.

It also contains the remaining front façade of the former early 19th century Heigold House, which features a detailed sketch of important early Whig Party leaders, displays the words "dedicated the greatest man in history, George Washington" etched across its front; the rest of the Fulton Street house has been razed.

Located on E. Washington Street is Copper & Kings, a brandy and absinthe distillery that offers daily tours and various community events.