Butere Girls High School grew out of a primary school founded by the Irish missionary Jane Elizabeth Chadwick, who arrived in Butere in 1916 and taught there until 1925, when she returned to Ireland.
[2] After facing infrastructure, management and discipline problems in the 1980s its academic performance deteriorated.
[2] In 2013 the school presented a controversial play, Shackles of Doom, by the playwright and future senator Cleophas Malala.
[4] In 2018 the school's performance of another play by Mabala, It is Well, earned them first place at Western Region Drama Festival.
[5] In 2016 the principal, Dorah Okalo, was removed from office after pressure from the Bishop of Butere.