Serving passenger and freight trains of the New York, Susquehanna and Western Railway, Butler served as the western terminus of service beginning in 1941, when passenger service was cut from Stroudsburg, Pennsylvania.

[8] Trains from Butler operated to Pavonia Terminal in Jersey City until December 12, 1958 and then Susquehanna Transfer in North Bergen until the discontinuation of service on June 30, 1966.

[3][2] The station depot, built in Stick–Eastlake architecture in 1888,[5] currently serves as the Butler Museum, a local nonprofit historical entity.

The National Register of Historic Places added Butler station to its listings on January 24, 2002 for its transportation significance.

[10] Operated by the Butler Historical Society, the museum's collections focus on the borough's social, industrial and cultural history.