Buxolestes is an extinct genus of semi-aquatic, non-placental eutherian mammals belonging to the family Pantolestidae.

Species in this genus were part of the first placental evolutionary radiation during the Middle Eocene (48-40 mya) and found in the Bracklesham Group and Wittering Formation of England, at the Messel Pit in Germany and in Bouxwiller, France.

Fossilized stomach contents confirm their semiaquatic freshwater habits.

The anatomy of these archaic "insectivorous" mammals is known through well-preserved Middle Eocene specimens found at Messel in Germany.

The skull is long, with large molars that appear to be adapted to a diet of molluscs with shells (freshwater clams and freshwater snails), but the predilection postulated from the dentition has not been confirmed.