During the late 18th century, Byculla was an extension of Mazagaon, one of the seven islands that originally formed the city of Mumbai.

The area was low-lying Flats inundated during the high tide through the Great Breach at Mahalaxmi.

Birthplace of Lady Patricia Helen Marie Rodrigues[2] The Byculla railway station was completed by 1857.

The resulting heavy traffic prompted city planners to develop major fly-overs in Byculla, as early as the 1980s.

Mumbai Central and Mahalakshmi on the Western Railway line and Dockyard Road and Reay Road stations on the Harbour Line of Mumbai Suburban Railway also lie close to Byculla.