Byers-Muma House is a historic home located in East Donegal Township, Lancaster County, Pennsylvania.

It is a 2+1⁄2-story, stone dwelling with Pennsylvania German Colonial and Georgian style design influences.

The original section was built about 1740, with additions about 1805, 1840–1850, and 1998.

Also on the property is a mid-18th century well.

[2][3] It was listed on the National Register of Historic Places in 2002.