Byron Foulger's motion picture career, however, did not begin in earnest until 1937, after he performed in December of that year on NBC Radio opposite Mae West in a racy "Adam and Eve" sketch on the network's popular variety program The Chase and Sanborn Hour.

[10] Foulger, who provided the voice of the serpent in the controversial biblical parody, was not banned for his brief supporting role; instead, his association with the sketch brought him widespread media attention and greater audience recognition.

Foulger played many parts–storekeepers, hotel desk clerks, morticians, professors, bank tellers, ministers, confidence men, and a host of other characterizations–usually timid, whining, weak-willed, shifty, sanctimonious, or sycophantic.

In a humorous coup, the actor was cast against type for the most prominent role of his career; he played the Devil opposite The Bowery Boys in Up in Smoke, and was billed in advertisements and posters as one of the film's three stars.

Beginning in 1950, Foulger made more than 90 appearances on television, in such programs as Death Valley Days, I Love Lucy, The Cisco Kid, My Little Margie, The Man Behind the Badge, The Lone Ranger, Maverick, Lawman, The Red Skelton Show, Rawhide, Wagon Train, Bonanza, Burke's Law, Daniel Boone, Hazel, The Patty Duke Show, The Monkees, Perry Mason, Laredo, Gunsmoke, and in 1965, The Beverly Hillbillies and The Addams Family.

"[5] A few examples of his other credits on television are his performances in the short-lived comedies My Mother the Car (as one of the villain's browbeaten advisors) and Captain Nice (as the hero's often silent father), as well as in two episodes of the crime drama The Mod Squad in 1968 and 1969.