Cascina (Italian pronunciation: [ˈkaʃʃina]) is a comune (municipality) in the Province of Pisa in the Italian region Tuscany, located about 60 kilometres (37 mi) west of Florence and about 13 kilometres (8 mi) southeast of Pisa.

Cascina is located on the left shore of the Arno River, on a markedly plain terrain.

The origin of the name is uncertain, but it could derive from Casina ("Small House"), or from the creek that crossed it (now disappeared), or from an Etruscan personal name, Latinized as Cassenius.

In the village of Zambra there is a 9th-century church with unusual wall paintings of fish in pre-Romanesque style.

At San Casciano, a frazione with c. 3,000 inhabitants, is a basilica, renovated in the 12th century in Pisane-Gothic style.