[3] Besides his fiction, and the translation work he does for a living, Aira also writes literary criticism, including monographic studies of Copi, the poet Alejandra Pizarnik, and the nineteenth-century British limerick and nonsense writer Edward Lear.

Aira also was the literary executor of the complete works of his friend the poet and novelist Osvaldo Lamborghini (1940–1985).

Aira has often spoken in interviews of elaborating an avant-garde aesthetic in which, rather than editing what he has written, he engages in a "flight forward" (fuga hacia adelante) to improvise a way out of the corners he writes himself into.

While his subject matter ranges from Surrealist or Dadaist themes to fantastic tales set in his Buenos Aires neighborhood of Flores, Aira also returns frequently to Argentina's nineteenth century (two books translated into English, The Hare and An Episode in the Life of a Landscape Painter, are examples of this; so is the best-known novel of his early years, Ema la cautiva (Emma, the Captive)).

His novella La prueba (1992) served as the basis—or point of departure, as only the first half-hour follows the novella—of Diego Lerman's film Tan de repente (Suddenly) (2002).