The neighbouring appellation of Luberon AOC stretches along its southern border and is separated from it by the Calavon river.

The three main areas of the region, the Malaucène basin, the foothills of the Mont Ventoux to the east of Carpentras and to the north of Cavaillon are less ravaged by the Mistral due to some shelter afforded by the Ventoux-Vaucluse-Luberon mountain range.

Other varieties which may be used to a maximum of 20%.The red wine is distinctly characterised by its aromas of black fruit, spice, and pepper.

White wines are produced from Clairette blanche, Bourboulenc, Grenache blanc, and Roussane (maximum 30%).

The vineyards are in the communes of Apt, Aubignan, Beaumettes, Beaumont-du-Ventoux, Bédoin, Blauvac, Bonnieux, Cabrières-d'Avignon, Caromb, Carpentras, Caseneuve, Crestet, Crillon-le-Brave, Entrechaux, Flassan, Fontaine-de-Vaucluse, Gargas, Gignac, Gordes, Goult, Joucas, Lagnes, La Roque-sur-Pernes, Le Barroux, Le Beaucet, Lioux, Loriol-du-Comtat, Malaucène, Malemort-du-Comtat, Maubec, Mazan, Méthamis, Modène, Mormoiron, Murs, Pernes, Robion, Roussillon, Rustrel, Saignon, Saumane, Saint-Didier, Saint-Hippolyte-le-Graveyron, Saint-Martin-de-Castillon, Saint-Pantaléon, Saint-Pierre-de-Vassols, Saint-Saturnin-lès-Apt, Venasque, Viens, Villars and Villes-sur-Auzon.