Line 500 is one of Căile Ferate Române's main lines in Romania, having a total length of 488 km (303 mi).

The main line, connecting Bucharest with the Ukrainian border near Chernivtsi, passes through the important cities of Ploiești, Buzău, Focșani, Adjud, Bacău, Roman, Pașcani, and Suceava.

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