Cầu Kè is a rural district (huyện) of Trà Vinh province in the Mekong Delta region of Vietnam.

As of 2003 the district had a population of 128,555.

[1] The district covers an area of 234 km².

The district capital lies at Cầu Kè.

This article about a location in Trà Vinh Province, Vietnam is a stub.