In chemistry, a C–H···O interaction is occasionally described as a special type of weak hydrogen bond.
These interactions frequently occur in the structures of important biomolecules like amino acids, proteins, sugars, DNA and RNA.
Glasstone studied properties of mixtures of acetone with different halogenated derivatives of hydrocarbons and realized that dipole moments of these mixtures differ from dipole moments of pure substances.
The first crystallographic analysis of C-H ⋯O hydrogen bonds were published by June Sutor in 1962.
[8] C–H···O interactions can be important in drug design, being present in structures of therapeutic proteins,[9][10] and nucleic acids.