[3] In continuous operation since its establishment in 1925, C. E. Byrd is also the eighth-largest high school in the United States of America as of February 2019.

[4][failed verification] Byrd students come from its neighborhood or throughout the entire school district through its selective math/science magnet program.

Byrd returned as a powerhouse by re-inventing itself as a Math and Science magnet school.

The 8 acres (3.2 ha) area comprising the school building and three other non-contributing properties were added to the National Register of Historic Places in 1991.

[2] The elaborate four story brick structure designed by Edward F. Neild has seen several alterations since its construction in 1924.