[1][2] Weyse was born at Altona in Holstein, which was in a personal union with Denmark.
While in Copenhagen, he studied music with Johann Abraham Peter Schulz.
Schulz helped Weyse get an unpaid internship at the Reformed Church in Copenhagen.
[3] He was best known for his vocal works, which included numerous singspiele, Christmas carols, a setting of the Te Deum and of the Miserere, over 30 cantatas,[1] and above all, lieder after poems by Matthias Claudius, Johann Heinrich Voss and Ludwig Christoph Heinrich Hölty.
A part of one of his works opens the "Cat's Duet" or "Duetto buffo di due gatti" usually attributed to Rossini.