Advances made during these collaborations included the exploration of transdisciplinary methods and the development of a science to support future complex systems design.

He also served on advisory committees for the U.S. Army, Air Force and Navy; Los Alamos Labs; Lockheed Research; and IBM.

He helped start several organizations including the Society for Design and Process Science (SDPS) where he served as board chairman until his passing.

[6][non-primary source needed] In 2006, SDPS created the Ramamoorthy-Yeh Endowment to support International transdisciplinary and transformative scientific research, education, and knowledge discrimination.

[7][non-primary source needed] In 2006 the International IEEE Conference on Tools of Artificial Intelligence (ICTAI) has established "the CV Ramamoorthy Best Paper Award".