The winners played in the 2011 CAF Super Cup.

Byes: Primeiro de Agosto (Angola), Coton Sport FC (Cameroon), Haras El Hodood (Egypt), FC 105 (Gabon), FAR Rabat (Morocco), Stade Malien (Mali), Enyimba (Nigeria), AS Vita Club (Congo DR), Simba (Tanzania), Étoile Sahel (Tunisia), CS Sfaxien (Tunisia), ZESCO United (Zambia), Académica do Soyo (Angola)2, Panthère Sportive du Ndé FC (Cameroon) 3.

2 Académica do Soyo were drawn against the champions of São Tomé and Príncipe, but the São Toméan FA did not send a team.

3 Panthère du Ndé were drawn against the champions of Benin, but the Beninese FA did not send a team.

The top scorers from the 2010 CAF Confederation Cup are as follows: