In operation since 1989, the São Paulo unit is located in the Sé Building, the bank's former regional headquarters, inaugurated in 1939 by Getúlio Vargas.

It maintains a permanent program of cultural events, including dance shows, theater plays, concerts, debates, video and cinema sessions, dramatic readings, lectures and temporary exhibitions, especially in the Visual arts' field.

In addition, the network also aimed to preserve Caixa Econômica Federal's collection, specialized in the institution's memory and the history of Brazil's financial system.

The institution has a permanent calendar of cultural events, with dance and theater shows, concerts, debates, dramatic readings, lectures, and workshops; and provides free internet access to visitors.

The building was designed to house the administrative offices of Caixa Econômica Federal in São Paulo after a series of financial operations carried out by the bank to acquire the properties surrounding the old 1907 headquarters, which was located in the old Travessa da Sé (now Wenceslau Brás Street).

Such monumentality is expressed, above all, by the portico and ionic columns of black piracaia granite at the main entrance, and in the marble coating on the internal walls of the first floor.

The hall has an octagonal shape and is preceded by a room adorned by a stained glass window with more than six meters high, executed by the Milanese artist Henrique Zucca, portraying the riches of São Paulo: agriculture (especially coffee), industry and livestock.

Its main activity is the preservation and promotion of Caixa Econômica Federal's memory and historical assets, also approaching issues such as the history of the national financial system and São Paulo's old downtown.

In the photographs' collection, a set of Hélio Becherini's works depicting the Sé Building and scenes from downtown São Paulo stand out.