The club was founded in October 2010 by a group of supporters of dissolved CF Ciudad de Murcia, which relocated in 2006, and was founded after CF Atlético Ciudad, its original reserve team which de facto acted as its first team for four years, was dissolved in 2010.

In its first season, Ciudad de Murcia promoted to Primera Autonómica after winning 22 of the 26 games played.

[citation needed] The club repeated the success in the next season, promoting to Preferente Autonómica despite finishing in the fourth position.

On May 10, 2015, Ciudad de Murcia promoted to Tercera División for the first time since its refoundation.

In February 2016, Ciudad de Murcia announced the creation of a women's team that would start competing in the Murcian Autonomous League.