CAVITEX–C-5 Link starts at Carlos P. Garcia Avenue (C-5) in Taguig near its interchange with the South Luzon Expressway (SLEX).

It then continues its course south of Ninoy Aquino International Airport until it meets its current terminus at C-5 Road Extension in Parañaque, near Moonwalk and a Shell station.

It will then pass by the Global Airport Business Park and Amvel City, where an interchange towards Dr. Santos Avenue and a future toll plaza are located.

In 1993, the Japan International Cooperation Agency (JICA) conducted a study on the proposed urban expressway system in Metro Manila.

However, in 2010, the project was scrapped in favor of the toll-free C-5 Road Extension, which was controversial for traversing several of then-Senator Manny Villar's properties in Parañaque and Las Piñas.

The first phase fills the gap between the C-5 main route and the C-5 Extension near Merville, Parañaque by constructing a 2.2-kilometer (1.4 mi) flyover over the South Luzon Expressway and Skyway.

[18] On June 23, 2024, the expressway's 1.9-kilometer (1.2 mi) Segment 2, which runs from CAVITEX to Parañaque (Sucat) interchanges, was opened to traffic.